Mitotane

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Storage 6 Adverse-effects 7 Drug-interactions 8 Test-interactions 9 Mechanism-of-action 10 More General Terms 11 Internet Database 12 References

Introduction

• Tradename: Lysodren.

Indications

• treatment of inoperable adrenal cortical carcinoma

Contraindications

• Caution:
• may impair ability to drive or operate hazardous equipment

Dosage

• Tabs: 500 mg

Storage

• Protect from light

Adverse-effects

• common (> 10%)

• diarrhea, hyperpigmentation, anorexia, depression, dizziness

• less common (1-10%)

• double vision, blurred vision, hemorrhagic cystitis, orthostatic hypotension, myalgia, fever, flushing of skin

• uncommon (< 1%)

• shortness of breath, wheezing, lethargy, somnolence, irritability, confusion, tremors, weakness, fatigue, headache, rash, nausea/vomiting

Drug-interactions

• barbiturates
• warfarin
• phenytoin
• CNS depressants

Test-interactions

• increases serum K+

Mechanism-of-action

• adrenocortical suppression

More General Terms

• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 4211

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Department of Veterans Affairs, VA National Formulary

mitotane (Lysodren)