Mitochondrial Permeability Transition Pore Complex

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 More General Terms 4 Additional Terms 5 References

Function

• voltage-dependent channel across:

• inner mitochondrial membrane
• outer mitochondrial membrane

• the open channel allows passage of molecules up to 15000 daltons, including

• cytochrome C, a key mediator of apoptosis
• adenine nucleotides ( ATP, ADP) through the outer mitochondrial membrane

• both components ( VDAC-1 & ANT) are voltage-gated.
• opening of ANT dissipates the H+ gradient across the inner mitochondrial membrane, uncoupling oxidative phosphorylation.

Structure

• components include:

• VDAC-1 ( outer mitochondrial membrane)
• ANT ( inner mitochondrial membrane)

More General Terms

• biochemistry

Additional Terms

• ADP/ATP translocase, adenine nucleotide translocase (ANT) or ADP/ATP carrier protein
• voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)

References

1. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: [1]
2. Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: [2]

mitochondrial permeability transition pore complex (PTPC)