Migratory Necrolytic Erythema
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Contents |
Etiology
- glucagonoma
- advanced hepatic cirrhosis
- bronchial carcinoma
- idiopathic (may be related to nutritional deficiency)
Epidemiology
- rare
- middle-aged to elderly
Pathology
- early skin lesions
- band-like upper epidermal necrosis
- retention of pyknotic nuclei
- pale keratinocyte cytoplasm
- vacuolar degeneration & lysis of organelles
Clinical-manifestations
- inflammatory plaques enlarge with central clearing, resulting in large areas that become confluent
- borders with vesiculation to bulla formation, crusting & scaling
- gyrate, circinate, arcuate & annular arrangement of lesions
- distribution:
- flexures
- intertriginous areas
- perioral
- perigenital
- fingertips red, shining, erosive
Laboratory
Differential-diagnosis
Management
- responds poorly to all forms of therapy
- partial response in some cases to zinc replacement
- surgical excision of glucagonoma may improve or resolve symptoms
More General Terms
Additional Terms
References
Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 512
