Metaproterenol

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Mechanism-of-action 8 More General Terms 9 Additional Terms 10 Internet Database 11 References

Introduction

• Tradenames: Alupent, Metaprel, Dey-Dose.

Indications

• relief/prevention of bronchospasm in patients with obstructive airway disease & exercise-induced bronchospasm

Dosage

• 0.1 mL/kg up to 0.3 mL 5% solution nebulized every 4 hours
• inhaler: 2-3 puffs every 3-4 hours
• oral: 20 mg PO TID/ QID
• children

• 6-9 yo: 10 mg PO TID/ QID
• <6 yo: 2 mg/kg/day PO

• Aerosol: 0.65 mg/metered dose Solution for inhalation: 5% (10 mL) Solution ready for inhalation: 0.4% (2.5 mL), 0.6 mL (2.5 mL)
• Tabs: 10 & 20 mg
• Syrup: 10 mg/5 mL (240 mL, 473 mL)

Pharmacokinetics

• onset of action:

• after inhalation is 1 minute
• after nebulizer 5-30 minutes

• peak effect: within 1 hour
• duration of action:

• 4-30 minutes [2]
• 1-5 hours [3]
  

• elimination via liver

Adverse-effects

• common (> 10%)

• nervousness, tremor

• less common (1-10%)

• bad taste, weakness, nausea/vomiting, trembling, muscle cramps, hypertension, increased sweating, headache, tachycardia, dizziness, coughing

• uncommon (< 1%)

• paradoxical bronchospasm

• other

• dose-related reflex tachycardia, tremor & palpitation
• decreased serum K+ concentration
  
• drug adverse effects of adrenergic receptor agonists
• drug adverse effects of beta-adrenergic receptor agonists

Drug-interactions

• beta blockers may antagonize effects

Mechanism-of-action

• beta-1 & beta-2 receptor agonist

More General Terms

• beta adrenergic receptor agonist
• antiasthmatic agent

Additional Terms

• albuterol (Salbutamol, Ventolin, Proventil)

Internet Database

PubChem: 4086
PubChem: 441333
PubChem: 22167

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
   - non formulary drug request (MDI)
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

metaproterenol (Alupent, Metaprel, Dey-Dose)