Mephenytoin

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Drug-interactions 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Introduction

• Tradename: Mesantoin.

Indications

• tonic-clonic seizures
• partial seizures
• partial seizures with motor symptoms
• partial complex seizures refractory to other agents
• (see phenytoin)

Dosage

• 100 mg PO BID/ TID/ QID [1]
• start 50-100 mg QD [2]
• increase 50-100 mg at weekly intervals
• do NOT increased dose more frequently than weekly
• average dose 200-600 mg/day

• Tabs: 100 mg.

Adverse-effects

• common (> 10%)

• psychiatric changes, slurred speech, trembling, constipation, nausea/vomiting, dizziness, drowsiness

• less common (1-10%)

• anorexia, weight loss, rash, headache, insomnia, leukopenia, hepatitis, increase in serum creatinine

• uncommon (< 1%)

• Stevens-Johnson syndrome or SLE-like syndrome, paresthesia, gingival hyperplasia, hypotension, bradycardia, cardiac arrhythmias, cardiovascular collapse, confusion, peripheral neuropathy, fever, ataxia, blood dyscrasia, thrombophlebitis, diplopia, nystagmus, blurred vision, lymphadenopathy, Hodgkin's disease-like syndrome, serum sickness, photophobia

• other (see phenytoin)
  

• drug adverse effects of anticonvulsants

Drug-interactions

• (see phenytoin)

More General Terms

• hydantoin; glycolylurea
• anticonvulsant

Additional Terms

• phenytoin; diphenylhydantoin; PTN (Dilantin, Dephenylan, Antilepsin)

Internet Database

PubChem: 4060
PubChem: 119127
PubChem: 107921

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

mephenytoin; methoin; methylphenylethylhydantoin (Mesantoin)