Meclofenamate

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Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Laboratory 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradenames: Meclomen {meclofenamate] & Ponstel {meclofenamic acid}.

Indications

• temporary relief of minor aches, pains, fever & inflammation
• primary dysmenorrhea

Dosage

• 50 mg PO TID/ QID, max 300 mg/day {meclofenamate}
• 250 mg PO QID {meclofenamic acid}.

• Tabs: 50, 100 mg { meclofenamate} 250 mg { meclofenamic acid}.

Pharmacokinetics

• duration of action: 2-4 hours
  

• elimination via liver

Adverse-effects

• common (> 10%)

• rash, dizziness, abdominal cramps, heartburn, indigestion, nausea

• less common (1-10%)

• itching, ringing in ears, fluid retention, headache, nervousness, vomiting

• uncommon (< 1%)

• congestive heart failure, hypertension, arrhythmia, epistaxis, confusion, hallucinations, aseptic meningitis, depression, peripheral neuropathy, urticaria, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, gastritis, GI ulceration, cystitis, agranulocytosis, anemia, hemolytic anemia, bone marrow suppression, leukopenia, thrombocytopenia, hepatitis, angioedema, allergic rhinitis, toxic amblyopia, blurred vision, conjunctivitis, dry eyes, decreased hearing, polyuria, shortness of breath, polydipsia, tachycardia, hot flashes, drowsiness, insomnia, acute renal failure
  
• drug adverse effects of NSAIDs

Laboratory

• specimen: plasma
• methods: HPLC, GC

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 4037
PubChem: 4036
PubChem: 22881
PubChem: 5282369
PubChem: 4038

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
3. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995

meclofenamate (Meclomen)