Mannose 6 Phosphate Receptor
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Contents |
Introduction
- See IGF 2 receptor for cation-independent mannose-6-phosphate receptor.
Function
- transport of phosphorylated lysosomal enzymes from Golgi & cell surface to lysosomes
- lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi, resulting receptor- ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates dissociation of the complex
- 5-20% of newly synthesized lysosomal enzymes escape binding to the mannose-6-phosphate receptors in the Golgi & are secreted
- binds GGA1, GGA2 GGA3
- optimal binding in the presence of divalent cations
Structure
- homodimer
- extracellular domain is homologous to the repeating units (~147 AA) of the cation-independent mannose 6-phosphate receptor
Compartment
More General Terms
Additional Terms
Internet Database
UniProt: [1]
Kegg: [2]
OMIM: 154540
References
UniProt [3]
