Malaria

From Anvita Health Wiki

Jump to: navigation, search

Contents

More Specific Terms

Introduction

  • From the Italian mal' aria meaning bad air.

Etiology

Epidemiology

  • sub-Saharan Africa

Pathology

Genetics

Clinical-manifestations

  • fever lasts 1-8 hours
  • recurrence of fever
  • in early phases of malaria, fever is frequently NOT periodic
  • drenching sweats

Laboratory

Complications

  • most deaths in African children < 4 years of age

Management

  • oral therapy for uncomplicated malaria
  • 10 mg/kg, followed by
  • 10 mg/kg at 24 h & 5 mg/kg at 48 h, or
  • 5 mg/kg at 12, 14 % 36 hours
  • for P. vivax or P. ovale, add primaquine 0.24 mg/kg for 14 days
  • 10 mg/kg IV over 8 h, followed by
  • 15 mg/kg over 24 h, or
  • 3.5 mg/kg IM or SC every 6 hours for a total dose of 25 mg/kg
  • oral therapy for uncomplicated malaria
  • 3.2 mg/kg IM followed by 1.6 mg/kg/day
  • artesunate - drug of choice for severe P. falciparum [6]
  • oral therapy for uncomplicated malaria
  • 10-12 mg/kg given in divided doses over 3-5 days
  • 4 mg/kg for 3 days
  • 4 mg/kg, followed by 1.5 mg/kg for 5 days
  • used alone
  • 10 to 12 mg/kg given in divided doses over 7 days
  • 4 mg/kg, followed by
  • 2 mg/kg on days 2 & 3 & 1 mg/kf on days 4-7
  • 2.4 mg/kg IV or IM, followed by
  • 1.2 mg/kg & 12 & 24 h, then
  • 1.2 mg/kg QD
  • oral therapy for uncomplicated malaria

More General Terms

Additional Terms

Internet Database

OMIM: 609148

References

  1. DeGowin & DeGowin's Diagnostic Examination, 6th edition, RL DeGowin (ed), McGraw Hill, NY 1994, pg 892
  2. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1260-64
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1180-89
  4. Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, American College of Physicians, Philadelphia 1998, 2006, 2009
  5. Prescriber's Letter 8(9):54 2001
  6. Dondorp A, Nosten F, Stepniewska K, Day N, White N; South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet. 2005 Aug 27-Sep 2;366(9487):717-25. PMID: [1]
    - Magill A, Panosian C. Making antimalarial agents available in the United States. N Engl J Med. 2005 Jul 28;353(4):335-7. Epub 2005 Jul 6. No abstract available. PMID: [2]
  7. Centers for Disease Control and Prevention; Filler SJ, MacArthur JR, Parise M, Wirtz R, Eliades MJ, Dasilva A, Steketee R. Locally acquired mosquito-transmitted malaria: a guide for investigations in the United States. MMWR Recomm Rep. 2006 Sep 8;55(RR-13):1-9. Corresponding NGC guideline withdrawn Dec 2011 PMID: [3]
  8. McMorran BJ et al. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 2009 Feb 6; 323:797. PMID: [4]
  9. Dondorp AM et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009 Jul 30; 361:455. <PubMed> PMID: [5] <Internet> [6]
  10. Malaria: NIH Institute and Center Resources [7]
    - Guidelines for Treatment of Malaria in the United States Centers for Disease Control [8]
    - CDC Malaria Hotline: (770) 488-7788 Mon-Fri 8 AM-4:30 PM EST (770) 488-7100 after hours, weekends and holidays
  11. National Guideline Clearinghouse
    - Guideline for laboratory diagnosis of malaria. British Committee for Standards in Haematology ngc-guideline: [9]
    - The prevention of malaria in pregnancy. Royal College of Obstetricians and Gynaecologists (RCOG) ngc-guideline: [10]
    - The diagnosis and treatment of malaria in pregnancy. Royal College of Obstetricians and Gynaecologists (RCOG) ngc-guideline: [11]

Retrieved from "http://www.anvita.info/wiki/Malaria"
Personal tools