Ly295427

From Anvita Health Wiki

Contents 1 Introduction 2 Mechanism-of-action 3 More General Terms 4 Additional Terms 5 References

Introduction

• Synthetic sterol.

Mechanism-of-action

• reduces plasma cholesterol by increasing expression of LDL receptor
• reverses oxysterol-induced suppression of sterol regulatory element binding protein ( SREBP) processing

More General Terms

• sterol
• anti-hyperlipidemic agent

Additional Terms

• low-density lipoprotein receptor; LDL receptor (LDLR)
• sterol regulatory element binding protein (SREBP)

References

- Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: [1] LY295427