Longevity

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• evolutionary biology of longevity

Introduction

• In reference to a long life. Also see mortality.
  

• See supercentenarian for World's oldest living persons.
  
• to extend healthy life span:

• diet is the most effective means

• Mediterranean diet & DASH diet associated with benefit
• calorie restriction extends maximum life span in rodents, yeast [2]
• calorie restriction extends mean life span & delays onset of age-associated pathologies in rhesus monkeys, including diabetes, cancer, cardiovascular disease, & brain atrophy [6]

• life style modification

• exercise
• not smoking
• alcohol in moderation, especially red wine

• pharmaceuticals & nutriceuticals are the most lucrative

• high-dose resveratrol mitigates delterious effects of high-calorie, high-fat diet in mice [3]
• rapamycin increases longevity in mice probaby via inhibition of mTOR[5]
• none ready for clinical implementation
  

• Genetic contributions to longevity:

• VV genotype (I450V) of CETP gene in humans promotes longevity & is protective against cognitive decline [4]
  

• Characteristics of American men favoring achieving centenarian status. [5]

• four or more children by age 30
• farmer
• slim or medium body build
• taller height marginally associated
  

• Personality traits of men associated with better longevity

• openness to new experiences
• conscientiousness

• Body mass index ( BMI)

• BMI > 25 in elderly women associated with diminished mortality [9]
• no relationship between BMI & mortality in elderly men [9]

More General Terms

• gerontology
• geriatrics

Additional Terms

• aging
• biology of aging
• centenarian
• life expectancy
• mortality
• supercentenarian

References

1. Netscape News cites Associated Press
2. Weindruch R and Walford RL, The retardation of aging and disease by dietary restriction. Charles C Thomas, Springfield IL, 1988
   - Guarente L, Picard F. Calorie restriction--the SIR2 connection. Cell. 2005 Feb 25;120(4):473-82. Review. PMID: [1]
3. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high- calorie diet. Nature. 2006 Nov 1; [Epub ahead of print] <PubMed> PMID: [2] <Internet> [3]
4. Barzilai N et al, A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006, 67:2170 PMID: [4]
5. Gavrilov L & Gavrilova N University of Chicago's Center on Aging Gerontological Society of America annual meeting, San Francisco, CA Nov 19, 2007 (per NetScape)
6. Colman RJ et al Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009 Jul 10; 325:201. PMID: [5]
7. Miller T Proceedings of the 38th Annual Meeting of the American Aging Association: Integrative Biology: Hormones, Signaling, and Aging. May 29-June 1, 2009, Scottsdale, AZ
   - Harrison DE et al Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009 Jul 8 <PubMed> PMID: [6] <Internet> [7]
8. Taylor MD et al Five factor model personality traits and all-cause mortality in the Edinburgh Artery Study cohort. Psychosom Med 2009 May 28 [8] PMID: [9]
9. Stessman J et al Normal body mass index rather than obesity predicts greater mortality in elderly people: The Jerusalem Longitudinal Study. J Am Geriatr Soc 2009 Dec; 57:2232 PMID: [10]

longevity