Long Chain Fatty Acid Coa Ligase 3
From Anvita Health Wiki
Contents |
Function
- acyl-CoA synthetases activate long-chain fatty acids for both synthesis of cellular lipids, & degradation via beta-oxidation
- ACSL3 mediates hepatic lipogenesis
- preferentially uses myristate, laurate, arachidonate & eicosapentaenoate as substrates ( putative)
- has mainly an anabolic role in energy metabolism
- required for incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins)
- ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA
- Cofactor: Mg+2 ( putative)
Structure
Compartment
- mitochondrial outer membrane
- peroxisome membrane
- microsome membrane
- endoplasmic reticulum membrane
- single-pass type 3 membrane protein ( putative)
More General Terms
Internet Database
Entrez gene: 2181
Kegg: [1]
OMIM: 602371
Prosite: [2]
UniProt: [3]
References
UniProt [4]
