Lipid Disorder

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Contents 1 More Specific Terms 2 Introduction 3 Pathology 4 Management 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• hyperlipidemia
• hyperlipoproteinemia (HLP)
• hypolipoproteinemia
• lipid metabolism, inborn error (lipid storage disease)
• lipodystrophy

Introduction

• see hyperlipidemia or more specific type

Pathology

• adverse consequences of dyslipidemia begin early in life [8]

Management

• screening with fasting lipid panel

• adults: men > 35 years of age (annual)
• women > 45 years of age (annual)
• children age 9-11
• young adults age 17-21

• dietary intervention is always indicated [7]

• limit total fat to 25-35% of calories
• limit saturated fat to < 7% of calories

• Mediterranean diet may result in better outcomes than low fat diet

More General Terms

• syndrome
• metabolic disease

Additional Terms

• lipid panel (fasting lipid panel, FLP)

References

1. Fletcher B, Berra K, Ades P, Braun LT, Burke LE, Durstine JL, Fair JM, Fletcher GF, Goff D, Hayman LL, Hiatt WR, Miller NH, Krauss R, Kris-Etherton P, Stone N, Wilterdink J, Winston M; Council on Cardiovascular Nursing; Council on Arteriosclerosis, Thrombosis, and Vascular Biology; Council on Basic Cardiovascular Sciences; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Nutrition, Physical Activity, and Metabolism; Council on Stroke; Preventive Cardiovascular Nurses Association. Managing abnormal blood lipids: a collaborative approach. Circulation. 2005 Nov 15;112(20):3184-209. <PubMed> PMID: [1] <Internet> [2]
2. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
3. Prescriber's Letter 15(8): 2008 COMMENTARY: Treatment of Hyperlipidemia in Children and Adolescents GUIDELINES: Lipid Screening and Cardiovascular Health in Childhood GUIDELINES: Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents GUIDELINES: Management of Dyslipidemia in Children and Adolescents with Diabetes Detail-Document#: [3] (subscription needed) [4]
4. Updated VA/DoD guideline on the management of dyslipidemia [5]
5. Screening for lipid disorders in adults National Guideline Clearinghouse United States Preventive Services Task Force (USPSTF) Department of Veterans Affairs, Department of Defense (VA/DoD). [6]
6. Prescriber's Letter 17(1): 2010 Second-Line Therapy of Dyslipidemia RESOURCE: Niacin Titration Schedule PATIENT HANDOUT: What You Should Know About Niacin COMMENTARY: Ezetimibe vs. Niacin for Atherosclerosis: The ARBITER 6-HALTS Study CHART: Non-Statin Lipid-Lowering Agents Detail-Document#: [7] (subscription needed) [8]
7. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
8. Pletcher MJ et al. Nonoptimal lipids commonly present in young adults and coronary calcium later in life: The CARDIA (Coronary Artery Risk Development in Young Adults) study. Ann Intern Med 2010 Aug 3; 153:137. PMID: [9]
9. Prescriber's Letter 19(1): 2012 Treatment of Hyperlipidemia in Children and Adolescents Detail-Document#: [10] (subscription needed) [11]
   - Daniels SR et al Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report (2011) [12]
10. National Guideline Clearinghouse
    - Lipid management in adults. Institute for Clinical Systems Improvement (ICSI) ngc-guideline: [13]
    - Screening for lipid disorders in children. United States Preventive Services Task Force ngc-guideline: [14]
    - Lipids. (Singapore) ngc-guideline: [15]
    - Screening and management of lipids. (University of Michigan Health System ) ngc-guideline: [16]
    - Managing abnormal blood lipids. A collaborative approach. American Heart Association ngc-guideline: [17]
    - Disorders of lipid metabolism evidence-based nutrition practice guideline. (American Dietetic Association) ngc-guideline: [18]
    - Position statement on lipid management--2005. National Heart Foundation of Australia ngc-guideline: [19]
    - Drug therapy of high-risk lipid abnormalities in children and adolescents. A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. ngc-guideline: [20]
    - Lipid modification. Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. National Collaborating Centre for Primary Care ngc-guideline: [21]
    - Treatment of dyslipidaemias. Finnish Medical Society Duodecim ngc-guideline: [22]

lipid disorder (dyslipidemia)