Light Chain Deposition Disease

From Anvita Health Wiki

Contents 1 Introduction 2 Etiology 3 Pathology 4 Laboratory 5 Management 6 More General Terms 7 Additional Terms 8 References

Introduction

• Systemic disorder.

Etiology

• overproduction & extracellular deposition of monoclonal light chains ( multiple myeloma)

Pathology

• eosinophilic glomerular nodules
• NOT congo-red positive
• granular rather than fibrillar
• a single class of light chains on immunofluorescent staining (80% kappa) found along the glomerular & tubular basement membranes Clinical manifestions:
• hypertension
• renal insufficiency

Laboratory

• proteinuria
• renal biopsy with immunofluorescent staining

Management

• chemotherapy similar to renal amyloidosis

More General Terms

• kidney disease; renal disease

Additional Terms

• myeloma cast nephropathy
• renal amyloidosis

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

light-chain deposition disease