Lactate Dehydrogenase Electrophoresis

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Contents 1 Indications 2 Clinical-significance 3 Notes 4 More General Terms 5 Additional Terms 6 References

Indications

• obsolete method of assessing recent mycocardial infarction

• largely replaced by troponin I in serum

Clinical-significance

• increase in LD-1 & LD-2 (anodic isozyme pattern)

• hemolysis
• ineffective erythropoiesis
• renal infarction
• germ cell tumors
• myocardial infarction
• muscular dysrophy

• increase in LD-3 (rare) (midzone pattern)

• infectious mononucleosis
• disseminated intravascular coagulation ( DIC)
• platelet destruction
• splenic necrosis
• manlignancy

• increase in LD-5 (cathodic isozyme pattern)

• hepatic damage

• most frequently from congestive heart failure in hospitalized patients

• skeletal muscle injury
• prostate carcinoma
• malignancy

Notes

• LD-5 1/2life: 10 hours
• LD-1 1/2 life: 100 hours

More General Terms

• electrophoresis
• clinical chemistry test

Additional Terms

• lactate dehydrogenase (LDH) in serum

References

1. McKenzie D and Henderson AR Electrophoresis of Lactate Dehydrogenase Isoenzymes CLINICALCHEMISTRY,Vol. 29, No. 1, 1983 [1]

lactate dehydrogenase (LDH) electrophoresis; lactate dehydrogenase isozymes in serum/plasma