Kras Gene Mutation Analysis

From Anvita Health Wiki

Contents 1 Pharmacology 2 Indications 3 Laboratory 4 More General Terms 5 Additional Terms 6 References

Pharmacology

• mutations in Kras associated with lack of effectiveness of

• cetuximab ( Erbitux)
• panitumumab ( Vectibix)

Indications

• defects in KRAS are a cause of

• acute myelogenous leukemia
• juvenile myelomonocytic leukemia
• Noonan syndrome 3
• cardiofaciocutaneous syndrome
• KRAS mutations are involved in cancer development, colorectal carcinoma

Laboratory

• LOINC: 21702-6, 21704-4, 53620-1

More General Terms

• molecular diagnostic test

Additional Terms

• K-ras 2 proto-oncogene

References

1. Lievre A et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008 Jan 20; 26:374. PMID: [1]
2. Patil DT, Fraser CR, Plesec TP. KRAS testing and its importance in colorectal cancer. Curr Oncol Rep. 2010 May;12(3):160-7. PMID: [2]
   - Tol J, Punt CJ. Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review. Clin Ther. 2010 Mar;32(3):437-53. PMID: [3]

Kras gene mutation analysis