Ketoprofen

From Anvita Health Wiki

Contents 1 Introduction 2 Dosage 3 Adverse-effects 4 Drug-interactions 5 More General Terms 6 Internet Database 7 References

Introduction

• Tradename: Orudis, Oruvail ( sustained-release).

Dosage

• 50-75 mg PO TID
• 200 mg PO QD ( sustained release)

• Tabs: 25, 50, 75 mg.
• Sustained-release: (Oruvail) 200 mg

Adverse-effects

• dyspepsia
• peptic ulceration
• gastrointestinal bleeding
• headache
• insomnia
• anxiety
• thrombocytopenia
• anemia
• agranulocytosis
• rash
• edema
• nephrotoxicity (rare)
• hepatotoxicity (rare)
  
• drug adverse effects of NSAIDs

Drug-interactions

• salicylates

• may divert metabolism to non- conjugated metabolites
• displace ketoprofen from plasma protein binding sites

• probenecid

• may inhibit conjugation of ketoprofen
• inhibits renal excretion of ketoprofen conjugates

• ketoprofen may inhibit renal excretion of:

• digoxin
• Li+
• methotrexate
  

• drug interaction(s) of lithium carbonate with NSAIDs
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of aspirin with NSAIDs
• drug interaction(s) of NSAIDs with beta blockers
• drug interaction(s) of NSAIDs with ARBs
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
• drug interaction(s) of NSAIDs & loop diuretics
• drug interaction(s) of NSAIDs & aspirin

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 3825
PubChem: 667550
PubChem: 42390

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995

ketoprofen (Orudis Oruvail)