Kazrin

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• component of the cornified envelope of keratinocytes
• may be involved in the interplay between adherens junctions & desmosomes
• function in the nucleus is not known
• isoform 2, isoform 3 & isoform 4 interact with PPL N-terminus

Structure

• belongs to the kazrin family
• contains 3 SAM (sterile alpha motif) domains

Compartment

• cytoplasm, cytoskeleton ( putative)
• isoform 2: cytoplasm. cell junction, desmosome, nucleus observed at the apical plasma mebrane of keratinocytes partially colocalizes with PPL & DP at desmosomes, & with PP at the interdesmosomal plasma membrane colocalizes with cortical actin-based membrane structures
• isoform 3: cytoplasm. cell junction, desmosome, nucleus observed at the apical plasma mebrane of keratinocytes partially colocalizes with PPL & DP at desmosomes, & with PP at the interdesmosomal plasma membrane colocalizes with cortical actin-based membrane structures
• isoform 4: cytoplasm. cell junction, desmosome, nucleus observed at the apical plasma mebrane of keratinocytes partially colocalizes with PPL & DP at desmosomes, & with PP at the interdesmosomal plasma membrane colocalizes with cortical actin-based membrane structures

Alternative-splicing

• named isoforms=5

Expression

• isoform 2, isoform 3 & isoform 4 are expressed in hair follicle & interfollicular epidermis (at protein level)
• isoform 2, isoform 3 & isoform 4 are expressed in several cell lines including keratinocytes & bladder & epidermoid carcinoma (at protein level)

More General Terms

• uncharacterized protein

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

Kazrin (KAZ KIAA1026)