Katanin P60 Atpase Containing Subunit A1

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 More General Terms 5 Internet Database 6 References

Function

• severs microtubules in vitro (ATP-dependent)
• rapid reorganization of cellular microtubule arrays ( putative)

• disassembly of interphase microtubules at G2-M transition
• microtubule release from the centrosome after nucleation
• depolymerization of microtubule end of mitotic spindles, proximal to centrosome, & subsequent poleward microtubule flux

• in neurons, microtubule release within cell body may allow their subsequent transport into axons by microtubule dependent motor proteins; this transport is required for axonal growth
• ATPase activity is stimulated by microtubules, which promote homooligomerization
• ATP dependent microtubule severing is stimulated by interaction KATNB1
• homooligomerizes into hexameric rings, promoted by microtubules
• interacts with KATNB1, targeting subunit ( putative)

Compartment

• cytoplasm, centrosome, spindle

Alternative-splicing

• named isoforms=2

More General Terms

• adenosine triphosphatase (ATPase)
• oligomerizing protein
• enzyme regulatory subunit

Internet Database

OMIM: 606696
Prosite: [1]
UniProt: [2]

References

UniProt [3]

katanin p60 ATPase-containing subunit A1 (katanin p60 subunit A1, p60 katanin, KATNA1)