Kappa Opioid Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• receptor for dynorphins
• inhibits neurotransmitter release by reducing Ca+2 currents & increasing K+ conductance
• may play a role in arousal & regulation of autonomic & neuroendocrine functions
• implication of dynorphins in LTP suggests OPRK1 may be involved as well
• interacts with SLC9A3R1
• interacts with GABARAPL1

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane

More General Terms

• endorphin receptor or opioid receptor
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 165196
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

1. UniProt [5]
2. Wikipedia; Note: Kappa opioid receptor entry [6]
3. Weisskopf MG, Zalutsky RA, Nicoll RA. The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation. Nature. 1993 Apr 1;362(6419):423-7. PMID: [7]
4. Reisine T, Bell GI. Molecular biology of opioid receptors. Trends Neurosci. 1993 Dec;16(12):506-10. Review. PMID: [8]

kappa opioid receptor; KOR-1 (OPRK1 OPRK)