Kainate Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Genetics 5 More General Terms 6 Internet Database 7 References

Function

• postsynaptic receptor for excitatory neurotransmitter L- glutamate in the central nervous system
• some variants of kainate receptors are somewhat permeable to Ca+2
• in some cases may behave as a metabotropic receptor [5]

Structure

• homo or heterotetramer

Compartment

• post-synpatic membrane
• some receptors may be presynaptic [5]

Genetics

• 3 of 5 kainate receptor subunits are formed after mRNA editing

• kainate 1 receptor ( GRIK1)
• kainate 2 receptor ( GRIK2)
• kainate 3 receptor ( GRIK3)

More General Terms

• ionotropic glutamate receptor
• Ca+2 channel
• Na+ channel
• multisubunit protein

Internet Database

Prosite: [1]

References

1. Choi 1988
2. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: [2]
3. Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: [3]
4. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994 Mar 3;330(9):613-22. Review. PMID: [4]
5. Rodriguez-Moreno A, Sihra TS. Metabotropic actions of kainate receptors in the CNS. J Neurochem. 2007 Dec;103(6):2121-35. Epub 2007 Sep 20. Review. PMID: [5]

kainate receptor