K+ Voltage Gated Channel Subfamily C Member 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 More General Terms 6 Internet Database 7 References

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
• channel properties are modulated by subunit assembly ( putative)
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits
• interacts with KCNC1, KCNE1, KCNE2 & KCNE3 ( putative)

Structure

• segment S4 is probably the voltage- sensor & is characterized by a series of positively charged amino acids at every third position
• tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, C (Shaw) subfamily

Compartment

• membrane

Alternative-splicing

• named isoforms=4

More General Terms

• transmembrane 6 protein
• K+ channel subfamily C
• glycoprotein

Internet Database

OMIM: 176256
UniProt: [1]

References

UniProt [2]

K+ voltage-gated channel subfamily C member 2 (voltage-gated K+ channel Kv3.2, KCNC2)