K+ Channel Subfamily U Member 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• testis-specific K+ channel
• activated by both intracellular pH & membrane voltage that mediates export of K+
• may be involved in sperm capacitation &/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH & membrane potential are known to occur
• in contrast to KCNMA1/ SLO1, it is not activated by Ca+2 or Mg+2

Structure

• homotetramer
• constitutes Ca+2-activated K+ channel ( putative)
• the S4 segment, which is characterized by a series of positively charged amino acids at every 3rd position, is part of the voltage- sensor ( putative)
• the pore-forming domain (also referred as P region) is imbedded into the membrane, & forms the selectivity filter of the pore; it contains the signature sequence of K+ channels that displays selectivity to K+ ( putative)
• the RCK N-terminal domain mediates the homotetramerization, thereby promoting assembly of monomers into functional K+ channel ( putative)
• the C-terminal cytosolic region confers the pH- dependence
• belongs to the K+ channel family
• contains 1 RCK N-terminal domain

Compartment

• membrane

Expression

• testis-specific

More General Terms

• transmembrane 7 protein
• K+ channel subfamily U
• testis-specific protein

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

K+ channel subfamily U member 1; Ca+2-activated K+ channel subunit alpha-3; Ca+2-activated K+ channel, subfamily M subunit alpha-3; Slowpoke homolog 3; KCa5 (KCNU1, KCNMA3, KCNMC1, SLO3)