K+ Channel Subfamily E Member 3
From Anvita Health Wiki
Contents |
Function
- ancillary protein that assembles as a beta subunit with a voltage-gated K+ channel complex of pore-forming alpha subunits
- modulates the gating kinetics & enhances stability of the channel complex
- association with KCNC4/ Kv3.4 is proposed to form the subthreshold voltage-gated K+ channel in skeletal muscle & to establish the resting membrane potential in muscle cells
- association with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated K+ channel involved in chloride secretion
Structure
- belongs to the K+ channel KCNE family
Compartment
- membrane; single-pass type 1 membrane protein
Expression
- widely expressed
- highest levels in kidney
- moderate levels in small intestine
Pathology
- defects in KCNE3 are a cause of
- hypokalemic periodic paralysis
- susceptibility to thyrotoxic periodic paralysis type 1
- defects in KCNE3 are the cause of Brugada syndrome type 6
More General Terms
Additional Terms
Internet Database
Entrez gene: 10008
Kegg: [1]
OMIM: 170400
OMIM: 188580
OMIM: 604433
OMIM: 613119
UniProt: [2]
References
UniProt [3]
