K+ Channel Subfamily B Member 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• mediates voltage-dependent K+ permeability of excitable membranes
• channels open or close in response to the voltage difference across the membrane, letting K+ pass in accordance with the electrochemical gradient
• phosphorylated ( putative)
• heteromultimer with KCNS1, KCNS2 & KCNS3

Structure

• the segment S4 is probably the voltage- sensor & is characterized by a series of positively charged amino acids at every third position
• the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.2/KCNB2 sub-subfamily

Compartment

• membrane

More General Terms

• transmembrane 6 protein
• K+ channel subfamily B
• glycoprotein

Internet Database

Entrez gene: 9312
Kegg: [1]
OMIM: 607738
UniProt: [2]

References

UniProt [3]

K+ voltage-gated channel subfamily B member 2; voltage-gated K+ channel subunit Kv2.2 (KCNB2)