Ip3 Receptor

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 Function 4 Structure 5 Alternative-splicing 6 Expression 7 More General Terms 8 Additional Terms 9 References

More Specific Terms

• inositol 1,4,5-trisphosphate receptor type 1; IP3 receptor-1; type 1 inositol 1,4,5-trisphosphate receptor; type 1 insP3 receptor; IP3 receptor isoform 1; insP3R1; IP3R (ITPR1 INSP3R1)
• inositol 1,4,5-trisphosphate receptor type 2; IP3 receptor-2; type 2 inositol 1,4,5-trisphosphate receptor; type 2 insP3 receptor; IP3 receptor isoform 2; insP3R2 (ITPR2)
• inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor-3; type 3 inositol 1,4,5-trisphosphate receptor; type 3 insP3 receptor; IP3 receptor isoform 3; insP3R3 (ITPR3)

Introduction

• Three distinct genes encode 3 similar IP3-receptors, with 69% sequence homology.

Function

• intracellular channel that mediates Ca+2 release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate
• suggested to have protein kinase activity, but functional significance of this suggestion is unknown
• binds to homer via PPXXF motif in proline-rich region in the N-terminal cytoplasmic domain.

Structure

• homologous to ryanodine receptor

Alternative-splicing

• different forms also produced by alternative splicing

Expression

• present in all tissues tested
• highest levels in cortex & cerebellum

More General Terms

• transmembrane 8 protein
• ionotropic receptor
• oligomerizing protein
• phosphoprotein
• glycoprotein
• Ca+2 channel

Additional Terms

• inositol-1,4,5-triphosphate (IP3)

References

1. Ferris et al Proc Natl Acad Sci U S A 1990 Mar;87(6):2147-51
2. Mignery GA, Sdhof TC. The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor. EMBO J. 1990 Dec;9(12):3893-8. PMID: [1]
3. Yamamoto H, Maeda N, Niinobe M, Miyamoto E, Mikoshiba K. Phosphorylation of P400 protein by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II. J Neurochem. 1989 Sep;53(3):917-23. PMID: [2]
4. Miyawaki A, Furuichi T, Maeda N, Mikoshiba K. Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line. Neuron. 1990 Jul;5(1):11-8. PMID: [3]
5. Taylor CW, Marshall IC. Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. Trends Biochem Sci. 1992 Oct;17(10):403-7. Review. Erratum in: Trends Biochem Sci 1992 Dec;17(12):493. PMID: [4]
6. Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: [5]

inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)