Inwardly Rectifying K+ Channel J2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• inwardly-rectifying K+ channel
• probably participates in establishing action potential waveform & excitability of neuronal & muscle tissues
• can be blocked by extracellular Ba+2 or Cs+2
• homomultimeric & heteromultimeric association with Kir2.3, resulting in an enhanced G-protein-induced current
• association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK & APBA1 plays a key role in its localization & trafficking ( putative)
• cardiac inward rectifier

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

• membrane

Expression

• heart, brain, placenta, lung, skeletal muscle, & kidney
• diffusely distributed throughout the brain

Pathology

• defects in KCNJ2 are the cause of

• long QT syndrome type 7
• short QT syndrome type 3

More General Terms

• inwardly-rectifying K+ channel subfamily J

Internet Database

Entrez gene: 3759
Kegg: [1]
OMIM: 170390
OMIM: 600681
OMIM: 609622
UniProt: [2]

References

1. UniProt [3]
2. GeneReviews [4]

inwardly-rectifying K+ channel J2; K+ channel, inwardly rectifying subfamily J member 2; inward rectifier K+ channel Kir2.1; cardiac inward rectifier K+ channel; IRK1 (KCNJ2, HIRK1)