Inwardly Rectifying K+ Channel

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 Function 4 Structure 5 More General Terms 6 References

More Specific Terms

• ATP-sensitive K+ channel (inwardly-rectifying K+ channel)
• G-protein gated K+ channel (inwardly-rectifying atrial K+ channel)
• inwardly-rectifying K+ channel subfamily J
• K+ voltage-gated channel subfamily H member 2; voltage-gated K+ channel subunit Kv11.1; ether-a-go-go-related gene K+ channel 1; ether-a-go-go-related protein 1; Eag-related protein 1; ERG-1; hERG-1; hERG1; H-ERG; Eag homolog (KCNH2, ERG, ERG1, HERG)

Introduction

• Protein products of a gene family encoding inwardly rectifying K+ channels

Function

• inwardly rectifying K+ channels are characterized by a greater tendancy to allow K+ to flow into the cell rather than out of it
• their voltage- dependence is regulated by the concentration of extracellular K+
• as extracellular K+ is increased, the voltage range of the channel opening shifts to more positive voltages
• the inward rectification is largely due to the blockage of outward current by intracellular Mg+2 [1]

Structure

• between the two transmembrane domains is an exoplasmic loop ( H5 region) containing the pore-forming region

More General Terms

• multiple transmembrane domain protein (type 3 membrane protein)
• K+ channel
• rectifier
• plasma membrane protein

References

1. Krapivinsky G et al The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995 Mar 9;374(6518):135-41. PMID: [1]

inwardly-rectifying K+ channel