Integrin Linked Protein Kinase
From Anvita Health Wiki
Contents |
Function
- receptor- proximal protein kinase regulating integrin- mediated signal transduction
- may act as a mediator of inside-out integrin signaling
- focal adhesion protein part of the complex ILK- PINCH
- this complex is considered to be one of the convergence points of integrin- & growth factor- signaling pathway
- possible role in mediating cell architecture, adhesion to integrin substrates & anchorage-dependent growth in epithelial cells
- phosphorylates beta-1 & beta-3 integrin subunit on Ser & Thr,
- phosphorylates AKT1 & GSK3B
- stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin (PI3-K-dependent), likely via the binding of Ptdins(3,4,5)P3 with a PH-like domain of ILK
- autophosphorylated on Ser
- interacts with cytoplasmic domain of integrin beta-1
- may also interact with integrin beta-2, integrin beta-3 &/or integrin beta-5
- interacts (via ANK repeats) with LIMS1 & LIMS2
- interacts with parvins & probably TGFB1I1
- interacts (via ANK repeats) with EPHA1 (via SAM domain);
Structure
- PH-like domain is involved in phosphatidylinositol phosphate binding
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
- contains 5 ANK repeats
- contains 1 protein kinase domain
Compartment
Expression
- expressed in heart > skeletal muscle, pancreas & kidney > placenta, lung & liver
More General Terms
Internet Database
Entrez gene: 3611
Kegg: [1]
OMIM: 602366
Prosite: [2]
Prosite: [3]
Prosite: [4]
Prosite: [5]
Prosite: [6]
UniProt: [7]
References
UniProt [8]
