Integrin Beta

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 More General Terms 5 Internet Database 6 References

More Specific Terms

• CD104 (integrin-beta 4, GP150, ITGB4)
• CD18 (integrin beta-2, L-CAM beta, ITGB2, CD18, MFI7)
• CD29 (integrin-beta 1, fibronectin receptor beta, VLA-4 beta, ITGB1, FNRB, MDF2, MSK12)
• CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)
• integrin-beta 5 (ITGB5)
• integrin-beta 6 (ITGB6)
• integrin-beta 7 (ITGB7)
• integrin-beta 8 (ITGB8)

Function

• regulatory subunit of integrins
• target integrins to focal adhesions ( ligand-dependent)

Structure

• composed of alpha & beta subunits selected from 16 alpha & 8 beta subunits that heterodimerize to produce more than 20 different receptors [3]
• the short cytoplasmic domains of the alpha & beta subunits do not have intrinsic enzyme activity, but appear to function by nucleating large complexes of cytoskeletal proteins & cytoskeletal-associated protein kinases
• integrin beta-4 is the exception, with a cytoplasmic domain in excess of 1000 residues
• integrin-alpha(s) contain highly divergent amino acid sequences, whereas the integrin-beta subunits show partial sequence conservation
• the integrin-beta(s) target integrins to focal adhesions in a ligand-independent manner, whereas the integrin-alpha(s) regulate the specificity of ligand-dependent interactions

More General Terms

• protein subunit
• cytoskeletal protein
• membrane protein

Internet Database

Prosite: [1]

References

1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
2. Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: [2]
3. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: [3]

integrin-beta