Insulin Protein

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 Pathology 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

More Specific Terms

• C-peptide
• proinsulin

Function

• hormone secreted by the islets of Langerhans in the pancreas
• regulates carbohydrate & fat metabolism
• induces hepatocytes & myocytes to internalize glucose from plasma & store it as glycogen in the liver & muscle, respectively
• inhibits release of glucagon

Structure

• heterodimer linked by 2 disulfide bonds
• a common precursor, proinsulin, gives rise to both insulin subunits & C-peptide
• apparently stored as a hexamer chelated by Zn+2 for stability

Pathology

• deficiency results in diabetes mellitus type 1
• insulin resistance or down-regulation of insulin receptors results in diabetes mellitus type 2
• insulinomas are islet cell tumors secreting insulin

More General Terms

• secreted peptide
• pancreatic hormone
• peptide precursor
• multisubunit protein

Additional Terms

• anti-insulin antibody
• insulin analog (synthetic insulins, recombinant insulins)
• insulin device (device for administering insulin)
• insulin in serum
• insulin receptor antagonist (insulin antagonist)
• insulin receptor; IR; (INSR)
• insulin resistance

Internet Database

Prosite: [1]
OMIM: 176730
Entrez gene: 3630
PubChem: 196300
PubChem: 3082397

References

- Wikipedia: Insulin [2] insulin protein