Iniparib

From Anvita Health Wiki

Contents 1 Indications 2 Mechanism-of-action 3 More General Terms 4 Internet Database 5 References

Indications

• improves outcomes in triple-negative* breast cancer when administered alongside standard chemotherapy

• * estrogen receptor negative, progesterone receptor negative, HER2 negative

Mechanism-of-action

• inhibits poly( ADP)ribose polymerase ( PARP), thus DNA repair of single-strand breaks
• unrepaired single strand breaks become double-strand breaks
• breast cancer patients with loss of BRCA1 or BRCA2 function are deficient in DNA double-strand break repair
• thus the PARP inibitor iniparib shows selective toxicity for tumor cells with homozygous BRCA1 or BRCA2 dysfunction

More General Terms

• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 9796068

References

1. O'Shaughnessy EC et al Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer N Eng J Med January 5, 2011 <PubMed> PMID: &dopt=Abstract <Internet> [1]
   - Carey LA and Sharpless NE PARP and Cancer - If It's Broke, Don't Fix It N Eng J Med January 5, 2011 <PubMed> PMID: [2] <Internet> [3]

iniparib