Inhibitor Of Nuclear Factor Kappa B Kinase Interacting Protein

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 Genetics 6 Notes 7 More General Terms 8 Internet Database 9 References

Function

• target of TP53/ p53 with pro- apoptotic function
• isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1 (Ikip1)
• N-glycosylated
• isoform 4 is glycosylated at Asn-154

Compartment

• endoplasmic reticulum membrane
• isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization

Alternative-splicing

• named isoforms=4

Expression

• expressed in vein endothelial cells
• isoform 4 is expressed in lung, kidney, spleen, thymus & skeletal muscle
• induced by X- irradiation

Genetics

• IKIP gene shares a common promoter with APAF1 from which the 2 genes are transcribed in the opposite direction

Notes

• variant in position: 122:Q->H (in dbSNP:rs12322444)

More General Terms

• glycoprotein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase interacting protein, IKK-interacting protein, IKIP)