Ingenol Mebutate

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Mechanism-of-action 6 More General Terms 7 References

Introduction

• diterpene ester extracted & purified from the plant Euphorbia peplus

Indications

• actinic keratosis

Dosage

• apply daily for 3 days
  

• Gel: 0.015%, 0.025%, 0.05%

Adverse-effects

• transient local skin responses consisting primarily of erythema, flaking/ scaling, & crusting
• no evidence of treatment-related scarring

Mechanism-of-action

• localized induction of necrosis followed by a transient inflammatory response

More General Terms

• dermatologic agent
• pharmaceutical herb (medicinal herb)
• diterpene

References

1. Anderson L et al Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. J Am Acad Dermatol 2009 Jun; 60:934. PMID: [1]
2. Prescriber's Letter 19(3): 2012 Actinic Keratoses Treatments Detail-Document#: [2] (subscription needed) [3]

ingenol mebutate (Picato)