Indacaterol

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Adverse-effects 4 Drug-interactions 5 Mechanism-of-action 6 More General Terms 7 References

Indications

• chronic obstructive pulmonary disease

Dosage

• once daily maintenance inhaler
  

• capsules:

• 75 mcg indacaterol inhalation powder
• capsules must be used with the neohaler device

Adverse-effects

• black box warning: possible increased risk of asthma-related death
• cough (6-25%)
• oropharyngeal pain (2%)
• nasopharyngitis (5%)
• headache (5%)
• nausea (2%)
  
• drug adverse effects of adrenergic receptor agonists
• drug adverse effects of beta-adrenergic receptor agonists

Drug-interactions

• consistent with those of other beta-2 adrenergic agonists
• concomitant use with MAO inhibitors, tricyclic antidepressants, & drugs that prolong the QTc interval may potentiate indacaterol's cardiovascular effects
  
• drug interaction(s) of beta-2 adrenergic receptor agonists with beta adrenergic receptor antagonists
• drug interaction(s) of beta-2 adrenergic receptor agonists with loop diuretics
• drug interaction(s) of beta-2 adrenergic receptor agonists with thiazide diuretics

Mechanism-of-action

• long-acting beta-2 adrenergic agonist
• bronchodilator, relaxation of bronchial smooth muscle

More General Terms

• beta-2 adrenergic receptor agonist

References

1. Wikipedia: Indacaterol [1]
2. Brooks M Medcape Oncology FDA Panel Backs Lower Dose of Indacaterol Maleate for COPD [2]
3. Prescriber's Letter 19(1): 2012 New Drug: Arcapta (Indacaterol) Detail-Document#: [3] (subscription needed) [4]

indacaterol (Arcapta)