Importin 9

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Notes 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• nuclear protein import as nuclear transport receptor
• receptor for nuclear localization signals ( NLS) in cargo substrates
• thought to mediate docking of importin/substrate complex to the nuclear pore complex through binding to nucleoporin
• the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism
• at the nucleoplasmic side of the nuclear pore complex, Ran binds to the importin, the importin/substrate complex dissociates & importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran
• directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- & GDP-bound forms of Ran between the cytoplasm & nucleus
• mediates nuclear import of H2B histone ( putative), RPS7 & RPL18A
• prevents cytoplasmic aggregation of RPS7 & RPL18A by shielding exposed basic domains
• may also import H2A, H3, H4 histones ( putative), RPL4 & RPL6
• binds with high affinity to RPS7 & RPL18A
• binding is coupled to RanGTP cycles
• may bind H2A, H3, H4 histones, RPL4 & RPL6 with low affinity
• interacts with PPP2R1A & PPP2R1B

Structure

• belongs to the importin beta family
• contains 1 importin N-terminal domain

Compartment

• cytoplasm ( putative), nucleus

Notes

• one of two Ran-binding protein 9
• Ran-binding protein M is the other

More General Terms

• importin beta subunit

Additional Terms

• importin complex (NLS-binding protein)
• Ran-binding protein M (Ran-binding protein 9, RanBP9, RanBP7, RanBPM, BPM90, BPM-L, RANBP9)

Internet Database

Kegg: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

importin 9 (Ran-binding protein 9, RanBP9, HSPC273, IPO9, IMP9, KIAA1192)