Importin 13

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• nuclear protein import as nuclear transport receptor
• serves as receptor for nuclear localization signals ( NLS) in cargo substrates
• thought to mediate docking of importin/substrate complex to the nuclear pore complex ( NPC) through binding to nucleoporin
• complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism
• at the nucleoplasmic side of the nuclear pore complex, Ran binds to importin, the importin/substrate complex dissociates & importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran
• directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- & GDP-bound forms of Ran between the cytoplasm & nucleus ( putative)
• mediates the nuclear import of UBC9, the RBM8A/ MAGOH complex, PAX6 & probably other members of the paired homeobox family
• also mediates nuclear export of eIF-1A
• cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13
• interacts with UBC9, RBM8A, eIF-1A & PAX6

Structure

• belongs to the importin beta family
• contains 14 HEAT repeats
• contains 1 importin N-terminal domain

Compartment

• cytoplasm, nucleus

Expression

• expressed in fetal brain, heart, intestine & kidney

More General Terms

• importin beta subunit

Additional Terms

• importin complex (NLS-binding protein)
• Ran-binding protein M (Ran-binding protein 9, RanBP9, RanBP7, RanBPM, BPM90, BPM-L, RANBP9)

Internet Database

Kegg: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

UniProt [5]

importin 13 (Ran-binding protein 13, RanBP13, IPO13, karyopherin 13, Kap13)