Immunoglobulin Superfamily Member 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor
• antagonizes activin A signaling in the presence or absence of inhibin B ( putative)
• necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription
• interacts with INHA ( putative)
• interacts with ACVR1B, interaction appears to be ligand- dependent as it is diminished by inhibin B & activin A
• interacts with ACVR2A, ACVR2B, ACVRL1 & BMPR1B

Structure

• contains 12 Ig-like C2-type domain ( immunoglobulin-like)

Compartment

• isoforms 1 & 2: membrane
• isoform 3: secreted ( putative)

Alternative-splicing

• named isoforms=3
• additional isoforms seem to exist

Expression

• highly expressed in pancreas, testis & fetal liver
• moderately expressed in heart, prostate & small intestine
• expressed at very low levels in brain, thymus, ovary, colon, fetal lung & fetal kidney
• expressed in muscle
• isoform 3 is expressed in pituitary gland

More General Terms

• glycoprotein
• membrane protein
• immunoglobulin superfamily protein

Internet Database

OMIM: 300137
UniProt: [1]

References

UniProt [2]

immunoglobulin superfamily member 1 (inhibin-binding protein, inhBP, immunoglobulin-like domain-containing protein 1, Pituitary gland specific factor 2, p120, IGSF1, IGDC1, KIAA0364, PGSF2)