Il 12 Receptor Beta 2
From Anvita Health Wiki
Contents |
Function
- with I12RB1, forms functional high affinity IL12 receptor
- signaling component coupling to the JAK2/ STAT4 pathway
- promotes the proliferation of T-cells as well as NK cells
- induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
- Il12RB2 binds JAK2 (via its N-terminal) through a membrane- proximal region of the cytoplasmic domain
- interaction, in vitro & in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation
- binds STAT4 through a membrane- distal C-terminal region
- on IL12 binding, phosphorylated on C-terminal Tyr by JAK2
- phosphorylation on Tyr-800 is required for STAT4 binding & activation, & for SOCS3 binding
Structure
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 2 subfamily
- contains 5 fibronectin F3 modules
Compartment
- membrane
Alternative-splicing
- named isoforms=2
Expression
- isoform 2 is expressed at similar levels in both naive & activated T-cells
- maximum levels in Th1 cells between day 3 & day 8 of activation
- in vitro, up-regulated by interferon alpha
Polymorphism
More General Terms
Internet Database
Kegg: [1]
OMIM: 601642
Prosite: [2]
Prosite: [3]
UniProt: [4]
Entrez gene: 3595
References
