Il 10 Receptor Beta

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 More General Terms 6 Internet Database 7 References

Function

• accessory subunit for receptors for IL10 & IL22
• serves as an accessory chain essential for the active IL10 receptor complex & to initiate IL10-induced signal transduction events

Structure

• belongs to the type II cytokine receptor family
• contains 2 fibronectin F3 modules

Compartment

• membrane

Pathology

• defects in IL10RB are associated with susceptibility to hepatitis B
• defects in IL10RB found in infantile-onset Crohn's disease

More General Terms

• protein subunit
• membrane protein
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 123889
OMIM: 610424
Prosite: [2]
UniProt: [3]
Entrez gene: 3588

References

1. UniProt [4]
2. SeattleSNPs [5]
3. Glocker E-O et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009 Nov 19; 361:2033 PMID: [6]
   - Kelsall B. Interleukin-10 in inflammatory bowel disease. N Engl J Med 2009 Nov 19; 361:2091. PMID: [7]

interleukin-10 receptor beta chain; IL-10R-B; IL-10R2; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; CRF2-4; CDw210b (IL10RB, CRFB4, D21S58, D21S66)