Idursulfase

From Anvita Health Wiki

Contents 1 Indications 2 Mechanism-of-action 3 More General Terms 4 References

Indications

• Hunter syndrome ( mucopolysaccharidosis 2) [2]

Mechanism-of-action

• enzyme replacement
• required for the lysosomal degradation of heparan sulfate & dermatan sulfate
• hydrolysis of the 2-sulfate groups of L- iduronate 2-sulfate units of dermatan sulfate, heparan sulfate & heparin

More General Terms

• iduronate-2-sulfatase (IDS, alpha-L-iduronate sulfate sulfatase)
• metabolic agent (metabolic modifier)

References

1. UniProt [1]
2. Prescriber's Letter 14(2): 2007 New drugs approved by the FDA in 2006 Detail-Document#: [2] (subscription needed) [3]
3. GeneReviews [4]

Idursulfase (iduronate-2-sulfatase)