Hypertension
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More Specific Terms
- chronic hypertension
- diastolic hypertension
- hypertension during pregnancy
- hypertensive crisis (malignant hypertension)
- hypertensive response to exercise (HRE)
- masked hypertension
- resistant hypertension
- salt-sensitive hypertension
- secondary hypertension
- systolic hypertension (hypertension in the elderly)
- white-coat hypertension
Introduction
- Elevation of arterial blood pressure above normal range (> 140/90). Commonly called high blood pressure, frequently abbreviated HTN.
Classification
- blood pressure (BP) classification (adults)
* systolic diastolic * normal < 120 < 80 * prehypertension [12,13] 120-139 80-89 * hypertension * stage I (mild) 140-159 90-99 * stage II (moderate) 160-179 100-109 * stage III (severe) 180-209 110-119 * stage IV (very severe) > 210 > 120
Etiology
- primary (essential) hypertension
-
- excessive dietary salt (see salt-sensitive HTN)
- excessive calorie intake
- stress
- African-American origin
- obesity
- family history of hypertension (see genetics)
- pharmacologic causes:
- clonidine withdrawal
- corticotropin ( ACTH)
- cyclosporin
- glucocorticoids
- monoamine oxidase ( MAO) inhibitors with sympathomimetics
- erythropoietin
- birth control pills
- non-steroidal anti-inflammatory action ( NSAIDs)
- sympathomimetics in over-the-counter cold remedies, i.e. pseudoephedrine, not significant
- acromegaly
- adrenal cortical hyperfunction
- renovascular disease (including renal artery stenosis)
- renal parenchymal disease
- coarctation of the aorta
- alcohol increases early morning blood pressure surge
- smoking increases early morning blood pressure surge
- 'white coat hypertension'
- sleep deprivation [14,16]
- sleep apnea [17]
Epidemiology
- 10-20% of persons age 25-45 years
- 30-40% of persons age 55-74 years
- 60% of persons > 65 years of age
Pathology
- renal sympathetic hyperactivity
- the renin angiotensin pathway is the major system influencing blood pressure
Genetics
- monogenic forms of hypertension
History
- duration, baseline blood pressure, chest or back pain, headaches, dyspnea, orthopnea, dizziness, blurred vision, nausea/vomiting, tremor, palpitations, diaphoresis, diarrhea, edema, hematuria, dysuria, polyuria, flank pain, thyroid disease, heart failure, alcohol withdrawal, non-compliance with antihypertensive agents (esp clonidine or beta-blocker)
Clinical-manifestations
- patients are generally asymptomatic
- clinical manifestations of target organ disease
- neurologic manifestations
- acute changes
- altered mental status including coma
- TIA, stroke
- headaches, dizziness, vertigo, tremors
- diplopia, diminished visual acuity
- focal deficits: numbness, weakness, slurred speech, cranial nerve palsies
- cardiac manifestations
- acute changes
- chronic changes
- clinical or ECG evidence of CAD
- LVH by ECG or echocardiogram
- S3 & S4 heart sounds
- lateral displacement of PMI
- vascular manifestations
- decreased peripheral pulses
- bruits - abdominal, femoral, carotid
- retinal manifestations
- acute changes
- chronic changes
- renal changes
- acute changes
- chronic changes
- elevated serum creatinine (> 1.5 mg/dL)
- proteinuria
- edema; b) striae; c) truncal obesity;
- hyperpigmentation; e) numbness of extremities;
- foot ulcers; g) muscle weakness; h) tachycardia
Diagnostic-criteria
- a blood pressure > 140/90 on 3 successive outpatient visits makes the diagnosis of hypertension
- a blood pressure > 140/90 based on an average of 2 or more readings > 1 minute apart at 2 or more visits [4]
- a single blood pressure reading is inadequate; multiple measurements are needed (2-5); combining home BP measurement with office-based measurements improves assessment [18]
Laboratory
- serum chemistries
-
- serum K+: hypokalemia (off diuretics) should give consideration to hyperaldosteronism & renal artery stenosis
- random U/A: leukocytes, protein, blood, glucose
- 24 hour urine: metanephrines, cortisol
- * refractory HTN or otherwise indicated
Diagnostic-procedures
-
- evidence of left ventricular hypertrophy suggests chronic hypertension
Radiology
- renal ultrasound to evaluate kidneys
- renal vein renin for hypertension refractory to therapy
- renal arteriogram or magnetic resonance angiogroaphy if renovascular hypertension suspected
- CXR: rib notching or indentation of or distal aortic arch with coarctation of the aorta
Complications
Management
- acute treatment of hypertension
- goal is reduction of blood pressure by 25%
- do not lower blood pressure rapidly to < 140/80
- adverse effect include: cerebral hypoperfusion & acute tubular necrosis ( ATN)
- sodium nitroprusside drip
- esmolol drip
- labetalol drip
- indicated when offending agent has alpha-adrenergic receptor stimulating properties, i.e. cocaine
- oral agents
- nifedipine 10 mg every hr
- captopril 10 mg every hr
- clonidine 0.1 mg every hr
- nitropaste
- hospitalize for:
- blood pressure > 210/120
- acute manifestations
- chronic hypertension (see chronic hypertension)
- screening recommended for all adults >= 18 years of age [15]
- Follow-up:
- Every 2 months for blood pressure 140-160/90-100
- Every 2 weeks for blood pressure 160-180/100-110
- Every week for blood pressure > 180/110
- hospitalize for blood pressure > 210/120
- Also consider:
More General Terms
Additional Terms
- ambulatory blood pressure monitoring (ABPM)
- antihypertensive agents & diabetes risk
- blood pressure (BP)
- blood pressure in the very old
- early morning blood pressure surge (EMBPS)
- etiology of arterial hypertension
- home blood pressure monitoring
- hypertension & diabetes
- hypertension clinical trials
- Joint National Committee On Prevention, Detection, Evaluation & Treatment of High Blood Pressure (JNC)
- poor prognostic indicators of hypertension
- prevention of hypertension
- systolic hypertension (hypertension in the elderly)
References
- Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39, 340-346
- Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 220-221
- Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 65-84
- Medical Knowledge Self Assessment Program (MKSAP) 11, 15, American College of Physicians, Philadelphia 1998, 2009
- Prescriber's Letter 7(12):79-70 2000
- Journal Watch 21(3):21, 2001 Mogensen et al Randomised controlled trial of dual blockade of renin- angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ 321:1440, 2000 PMID: [1]
- Journal Watch 22(8):61, 2002 Oliveria SA et al Physician-related barriers to the effective management of uncontrolled hypertension. Arch Intern Med 162:413, 2002 PMID: [2]
- Journal Watch 22(8):61, 2002 Boutitie F et al J-shaped relationship between blood pressure and mortality in hypertensive patients: new insights from a meta-analysis of individual-patient data. Ann Intern Med 136:438, 2002 PMID: [3]
- Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
- Prescriber's Letter 10(1):1 2003
- Prescriber's Letter 10(4):19 2003
- Journal Watch 24(1):5, 2004 Chobanian AV et al The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289:2560, 2003 PMID: [4]
- Chobanian AV et al Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206, 2003 PMID: [5]
- Cappuccio FP et al, Gender-specific associations of short sleep duration with prevalent and incident hypertension: The Whitehall II Study. Hypertension 2007, 50:693 PMID: [6]
- US Preventive Services Task Force. Screening for high blood pressure: US Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med 2007, 147:783 PMID: [7]
- Wolff T and Miller T Evidence for the US Preventive Services Task Force recommendation on screening for high blood pressure. Ann Intern Med 2007, 147:787 PMID: [8] - Knutson KL et al Association Between Sleep and Blood Pressure in Midlife The CARDIA Sleep Study Arch Intern Med. 2009;169(11):1055-1061 PMID: [9]
- O'Connor GT et al Prospective study of sleep-disordered breathing and hypertension: The Sleep Heart Health Study. Am J Respir Crit Care Med 2009, 179:1159 PMID: [10]
- Powers BJ et al Measuring Blood Pressure for Decision Making and Quality Reporting: Where and How Many Measures? Annals of Internal Medicine: June 20, 2011 154(12):781-788 <PubMed> PMID: [11] <Internet> [12]
- Appel LJ et al Improving the Measurement of Blood Pressure: Is It Time for Regulated Standards? Annals of Internal Medicine: June 20, 2011 154(12):838-39 <PubMed> PMID: [13] <Internet> [14] - High Blood Pressure: NIH Institute and Center Resources [15]
- National Guideline Clearinghouse 2007 guidelines for the management of arterial hypertension. European Society of Cardiology ngc-guideline: [16]
- Hypertension diagnosis and treatment. (Institute for Clinical Systems Improvement) ngc-guideline: [17]
- Screening for high blood pressure: U.S. Preventive Services Task Force reaffirmation recommendation statement. ngc-guideline: [18]
- VHA/DoD clinical practice guideline for the diagnosis and management of hypertension in the primary care setting. ngc-guideline: [19]
- American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of hypertension. (American Association of Clinical Endocrinologists) ngc-guideline: [20]
- Routine chest radiographs in uncomplicated hypertension. (American College of Radiology) ngc-guideline: [21]
- Guide to management of hypertension 2008. Assessing and managing raised blood pressure in adults. National Heart Foundation of Australia ngc-guideline: [22]
- Hypertension - detection, diagnosis and management. Medical Services Commission, British Columbia ngc-guideline: [23]
- Essential hypertension. University of Michigan Health System. ngc-guideline: [24]
- Clinical practice guidelines on arterial hypertension. 2007 update. Basque Health System - Osakidetza ngc-guideline: [25]
