Human Papillomavirus Dna

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Contents 1 Indications 2 Specimen 3 Notes 4 More General Terms 5 Additional Terms 6 References

Indications

• viral infection with papillomavirus
• recommended as adjunctive testing to cervical cytology in women > 30 years of age (see recommendations for performing Pap smears) [2]

Specimen

• cervical smears
• biopsies or scrapings
• anogenital tissue
• store tissue at -20 degrees C or below

Notes

• over 50 recognized types
• better sensivitity (94.6% vs 55.4%) but poorer specificity (94.1% vs 96.8%) for high-grade cervical intraepithelial neoplasia than Pap smear [3]
• several different tests [3,4]

More General Terms

• molecular diagnostic test

Additional Terms

• human papillomavirus (HPV) genotyping
• Papanicolaou (Pap) smear
• papillomavirus
• PCR/southern blot/in-situ hybridization for cervical cancer

References

1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
2. Journal Watch 24(6):452, 2004 Wright TC Jr et al, Obstet Gynecol 103:304, 2004 PMID: [1]
3. Mayrand M-H et al, Human papilloma DNA versus Papanicolau screening tests for cervical cancer. N Engl J Med 2007, 357:1579 PMID: [2]
4. FDA Approves Roche’s HPV Test for Identifying Women at Highest Risk for Cervical Cancer, April 20, 2011 [3]
5. National Guideline Clearinghouse Initial management of abnormal cervical cytology (Pap smear) and HPV testing. Institute for Clinical Systems Improvement ngc-guideline: [4]

human papillomavirus (HPV) DNA