Homeodomain Interacting Protein Kinase 3

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Expression 4 More General Terms 5 Internet Database 6 References

Function

• negatively regulates apoptosis via FADD phosphorylation
• interacts with & stabilizes ligand-bound androgen receptor
• enhances androgen receptor-mediated transcription
• may act as a transcriptional corepressor for NK homeodomain transcription factors
• interacts with Nkx1-2, FAS & DAXX
• probably part of a complex consisiting of HIPK3, FAS & FADD

Compartment

• nuclear & cytoplasmic

Expression

• overexpressed in multidrug resistant cells
• highly expressed in heart & skeletal muscle

More General Terms

• serine/threonine kinase

Internet Database

OMIM: 604424
Prosite: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

UniProt [5]

homeodomain-interacting protein kinase 3; homolog of protein kinase YAK1; Fas-interacting serine/threonine protein kinase; FIST, androgen receptor-interacting nuclear protein kinase; ANPK (HIPK3, DYRK6, FIST3, PKY)