Hla Class I Histocompatibility Antigen Cw 6 Alpha Chain

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 Polymorphism 6 More General Terms 7 Internet Database 8 References

Function

• role in the presentation of foreign antigens to the immune system
• heterodimer of an alpha chain & a beta chain ( beta-2-microglobulin)
• interacts with human herpesvirus 8 MIR1 protein
• polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein; this targets HLA-Cw6a for rapid degradation via the ubiquitin system ( putative)

Structure

• belongs to the MHC class I family
• contains 1 Ig-like C1-type domain ( immunoglobulin-like domain)

Compartment

• membrane

Pathology

• genetic variation in HLA-C6a is associated with susceptibility to psoriasis 1
• HLA-Cw*0602 is a risk factor that confers susceptibility to psoriasis (PSORS1) [MIM:177900].

Polymorphism

• alleles of Cw-6:

• Cw*0602
• Cw*0603
• Cw*0604

More General Terms

• glycoprotein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

HLA class I histocompatibility antigen, Cw-6 alpha chain; MHC class I antigen Cw*6 (HLA-Cw6a, HLACw6a)