Hla Class I Histocompatibility Antigen Cw 18 Alpha Chain

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Polymorphism 5 More General Terms 6 Internet Database 7 References

Function

• role in the presentation of foreign antigens to the immune system

• heterodimer of an alpha chain & a beta chain (beta-2- microglobulin)

• interacts with human herpesvirus 8 MIR1 protein
• polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein; this targets HLA-Cw18a for rapid degradation via the ubiquitin system

Structure

• belongs to the MHC class I family
• contains 1 Ig-like C1-type domain ( immunoglobulin-like domain)

Compartment

• membrane

Polymorphism

• alleles of Cw-18:

• Cw*1801(Cw*04GB)
• Cw*1802 (Cw*18GB)

More General Terms

• glycoprotein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

HLA class I histocompatibility antigen, Cw-18 alpha chain; MHC class I antigen Cw*18 (HLA-Cw18a, HLACw18a)