Hla Class I Histocompatibility Antigen B 82 Alpha Chain

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Polymorphism 5 More General Terms 6 Internet Database 7 References

Function

• role in the presentation of foreign antigens to the immune system
• heterodimer of an alpha chain & a beta chain ( beta-2-microglobulin)
• interacts with human herpesvirus 8 MIR1 protein
• polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein; this targets HLA-B82a for rapid degradation via the ubiquitin system ( putative)

Structure

• belongs to the MHC class I family
• contains 1 Ig-like C1-type domain ( immunoglobulin-like domain)

Compartment

• membrane

Polymorphism

• alleles of B-82L

• B*8201
• B*8202

More General Terms

• glycoprotein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

HLA class I histocompatibility antigen, B-82 alpha chain; MHC class I antigen B*82 (HLA-B82a, HLAB82a)