Hiv 1 Coreceptor Tropism

From Anvita Health Wiki

Contents 1 Indications 2 Laboratory 3 Clinical-significance 4 More General Terms 5 References

Indications

• HIV1 infection

Laboratory

• LOINC: 50790-5, 53923-9, 57182-8

Clinical-significance

• determines eligibility for maraviroc ( Selzentry) therapy by determining variations in the HIV-1 envelope V3 loop by PCR [1]
• HIV1 tropism testing determines ability of HIV-1 isolate to infect & replicate in monocytes [3]
• indirectly measures ability of HIV1 to gain access to monocytes via chemokine receptor CCR5

More General Terms

• molecular diagnostic test
• HIV laboratory testing

References

1. HIV-1 Coreceptor tropism Quest Diagnostics [1]
2. Prosperi MCF et al Comparative determination of HIV-1 coreceptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping Retrovirology 2010, 7:56 doi:10.1186/1742-4690-7-56 [2]
3. O'Brien WA et al HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain Nature 1990, 348:69-73 PMID: [3]

HIV-1 coreceptor tropism (Trofile)