Hephaestin

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• ferroxidase for Fe+2 to Fe+3 conversion
• copper transport & homeostasis
• iron homeostasis

• may mediate iron efflux associated to ferroportin 1
  

• Cofactor: binds 6 Cu+/Cu+2 per monomer

Structure

• belongs to the multicopper oxidase family
• contains 6 plastocyanin-like domains

Compartment

• membrane

Alternative-splicing

• named isoforms=2

Expression

• detected in breast, colon, bone trabecural cells, fibroblasts

More General Terms

• oxidoreductase
• carrier protein (transporter)
• glycoprotein
• metalloprotein
• membrane protein

Internet Database

OMIM: 300167
Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

hephaestin (HEPH, KIAA0698, UNQ2562/PRO6242)