Hepatocyte Cell Adhesion Molecule
From Anvita Health Wiki
Contents |
Function
- role in regulating cell motility & cell- matrix interactions
- may inhibit cell growth through suppression of cell proliferation
- homodimer, dimer formation occurs predominantly through cis interactions on the cell surface
Structure
- cytoplasmic domain plays an important role in regulation of cell- matrix adhesion & cell motility
- contains 1 Ig-like C2-type domain ( immunoglobulin-like)
- contains 1 Ig-like V-type domain ( immunoglobulin-like)
- N-glycosylated
Compartment
- cytoplasm, membrane, cytoplasmic side
- in MCF7 breast carcinoma & hepatic Hep3B & HepG2 cell lines, localization of HEPACAM is cell density-dependent
- in well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, & at cell surface of protusions
- in confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts
- colocalizes with CDH1
Alternative-splicing
- named isoforms=2
Expression
- down-regulated in 20 out of 23 of hepatocellular carcinoma (HCC) samples & is undetectable in 5 HCC cell lines tested
More General Terms
Internet Database
UniProt: [1]
References
UniProt [2]
