Hemoperfusion

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Mechanism-of-action 4 Complications 5 More General Terms 6 References

Introduction

• Passage of blood through columns of adsorptive material, such as activated charcoal, to remove toxic substances from the blood. [from hemo + L. perfusio, to pass through]

Indications

• poisoning, drug overdose

• of particular benefit for drugs that are highly protein- bound
• theophylline poisoning, carbamazepine poisoning

Mechanism-of-action

• removes drugs that are both polar & non polar
• not limited by water solubility or molecular weight

Complications

• thrombocytopenia (30% reduction in platelets is common)
• leukopenia
• hypoglycemia
• hypocalcemia
• hemorrhage secondary to heparinization

More General Terms

• emergency medicine
• clinical toxicology
• clinical procedure

References

1. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
2. Daubert GP, Emergency Medicine, University of California, Davis

hemoperfusion